This study aims to measure efficiency and productivity and determine the factors that influence the level of efficiency of Islamic Banks in the Middle East and Southeast Asia in 2014-2018. Calculation of the level of efficiency in this study is relative, not absolute. This study uses the Data Envelopment Analysis (DEA) method. This research consists of 3 input variables namely Operational Costs (X1) and Salary Costs (X2) Socialization Costs (X3) and 2 Output Operational Income (Y1) and Distribution or Financing (Y2) output variables )). There are 5 Sharia Banks that are perfectly efficient (Constant). And the rest is fluctuating (Increasing and Decreasing). Islamic banks with the lowest relative efficiency levels are in Southeast Asia.