The efficiency of the control of harmful organisms of the batch of grain cereal seeds is an essential component in the effort to maintain unaltered the quality of the stored seed lots, in terms of physical integrity, especially their longevity, by maintaining germination indices at the optimum level, for as long as possible. The primary purpose of the research was to identify and describe the specific pests and their grouping, depending on the specific types of attack, as well as estimating potential damage in the event of an uncontrolled attack. The second component of the research was to monitor the possible ways of infestation with the identified harmful organisms of storage as well as the specific way in which they can be controlled so as not to produce irreversible damage to the consignments of stored grain cereal seed. The paper proposes concrete control schemes that harmoniously combine physicochemical methods and biological methods to prevent and combat pest infestation during storage. Modern theories of protection against harmful organisms are based on the economic threshold of harm (PED), which can be defined by the level of losses caused by the harmful organisms, the cost / benefit ratio and the expenditure of resources for protection actions. The economic pest threshold for insects in seed lots for storage is close to zero, when certified seed lots come from controlled and admitted seed crops, free of living harmful organisms and without signs of infestation.